Table 2. Analysis of transcriptional response to transcription factor deletion

Transcription Factor	Genome wide		B+/C+			B+/C-
Transcription Factor	Mean	SD	Mean	SD	-log₁₀(P)	Mean	SD	-log₁₀(P)
Dig1	0.759	0.198	0.567	0.360	3.76	0.846	0.080	0.04
Gcn4	0.785	0.177	0.294	0.329	28.23	0.793	0.170	0.24
Hir2	0.724	0.218	0.180	0.295	4.00	0.760	0.194	0.14
Mbp1	0.830	0.121	0.541	0.324	27.86	0.770	0.172	2.79
Swi4	0.524	0.338	0.348	0.352	4.89	0.533	0.333	0.24
Swi5	0.744	0.204	0.583	0.373	5.98	0.759	0.186	0.17
Yap1	0.756	0.201	0.471	0.376	7.66	0.587	0.337	2.67

Analysis of transcriptional response to transcription factor deletion. Mean and standard deviation of gene expression log-ratio between mutant and wild type as obtained in Hughes et al. were calculated for all genes in the genome, as well as for the B+/C+ and B+/C- groups. A sample t-test was performed to determine the significance of the change in expression. The B+/C+ genes show a significant change in mRNA expression for the 7 transcription factors for which deletion and ChIP data is available. By contrast, the response of the B+/C- genes is insignificant for most transcription factors.